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Effectiveness and safety of iodopovidone in an experimental pleurodesis model
Teixeira, Lisete R.; Vargas, Francisco S.; Puka, Juliana; Acencio, Milena M. P.; Antonangelo, Leila; Terra, Ricardo M.; Damico, Francisco M.; Pitta, Fabio G.; Marchi, Evaldo.
  • Teixeira, Lisete R.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Vargas, Francisco S.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Puka, Juliana; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Acencio, Milena M. P.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Antonangelo, Leila; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Terra, Ricardo M.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Damico, Francisco M.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Pitta, Fabio G.; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
  • Marchi, Evaldo; Universidade de São Paulo. Faculdade de Medicina. Heart Institute (InCor). Pulmonary Division and Thoracic Surgery. São Paulo. BR
Clinics ; 68(4): 557-562, abr. 2013. tab, graf
Article in English | LILACS | ID: lil-674244
ABSTRACT

OBJECTIVES:

Chemical pleurodesis is an important therapeutic tool to control recurrent malignant pleural effusion. Among the various sclerosing agents, iodopovidone is considered effective and safe. However, in a recent study, ocular changes were described after iodopovidone was used in recurrent pneumothorax. The aim of the study was to evaluate the efficacy and morbidity of iodopovidone pleurodesis in an experimental model.

METHODS:

New Zealand rabbits were submitted to intrapleural injection of iodopovidone at concentrations of 2%, 4% and 10%. Biochemical (lactic dehydrogenase, proteins, triiodothyronine, free thyroxine, urea and creatinine) and immunological (Interleukin-8 [IL-8], VEGF and TGFβ) parameters were measured in the pleural fluid and blood. After 1, 3, 7, 14 and 28 days, groups of animals were euthanized, and macro- (pleura) and microscopic (pleura and retina) analyses were performed.

RESULTS:

An early pleural inflammatory response with low systemic repercussion was observed without corresponding changes in thyroid or renal function. The higher concentrations (4% and 10%) correlated with greater initial exudation, and maximum pleural thickening was observed after 28 days. No changes were observed in the retinal pigment epithelium of the rabbits.

CONCLUSION:

Iodopovidone is considered to be an effective and safe sclerosing agent in this animal model. However, its efficacy, tolerance and safety in humans should be further evaluated. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Povidone-Iodine / Sclerosing Solutions / Pleural Effusion, Malignant / Pleurodesis Type of study: Prognostic study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Povidone-Iodine / Sclerosing Solutions / Pleural Effusion, Malignant / Pleurodesis Type of study: Prognostic study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR