Gabaergic fibers from substantia nigra para reticulata modulate escape bahavior induced by midbrain central gray stimulation
Braz. j. med. biol. res
;
22(1): 111-4, 1989. ilus
Article
in English
| LILACS
| ID: lil-67511
ABSTRACT
Eletrical stimulation or microinjection of GABA antagonists into the dorsal periaqueductal gray (DPAG) produces escape behavior. In order to determine whether the nigrocollicular gabaergic fibers exert some control over this behavior, rats bearing kainic acid lesion of the substantia nigra pars reticulata were submitted to microinjections of bicuculline or electrical stimulation of the DPAG at the escape threshold. Rats thus treated exhibited a significant decrease in the escape threshold while bicuculline increased the expression of flight behavior. These results suggest an inhibitory control of gabaergic fibers from the substantia nigra pars reticulata on aversive behavior induced by DPAG stimulation
Search on Google
Index:
LILACS (Americas)
Main subject:
Runaway Behavior
/
Bicuculline
/
Substantia Nigra
/
Gamma-Aminobutyric Acid
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Project document
Similar
MEDLINE
...
LILACS
LIS