Otostegia persica extraction on healing process of burn wounds
Acta cir. bras
;
28(6): 407-411, June 2013. ilus, tab
Article
in English
| LILACS
| ID: lil-675573
ABSTRACT
PURPOSE:
To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects.METHODS:
Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically.RESULTS:
Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation.CONCLUSION:
Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Wound Healing
/
Burns
/
Plant Extracts
/
Lamiaceae
/
Anti-Inflammatory Agents
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Islamic Azad University/IR
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