Your browser doesn't support javascript.
loading
Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats
Melo, José Ulisses de Souza; Melo, Radamés Bezerra; Santos, Jefferson Menezes Viana; Campos Júnior, Manoel Messias; Guimarães, Sérgio Botelho; Vasconcelos, Paulo Roberto Leitão.
  • Melo, José Ulisses de Souza; UFC. Department of Surgery. BR
  • Melo, Radamés Bezerra; UFC. Department of Surgery. BR
  • Santos, Jefferson Menezes Viana; UFC. Department of Surgery. BR
  • Campos Júnior, Manoel Messias; UFC. Department of Surgery. BR
  • Guimarães, Sérgio Botelho; UFC. Department of Surgery. BR
  • Vasconcelos, Paulo Roberto Leitão; UFC. Department of Surgery. BR
Acta cir. bras ; 28(6): 435-440, June 2013. ilus
Article in English | LILACS | ID: lil-675578
ABSTRACT

PURPOSE:

To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH).

METHODS:

Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats received daily intraperitoneal (ip) injections of saline (NaCl 0.9% solution) 0.1 mL/kg for 14 days; G2 animals received daily ip injections of TRT 0.1% 1.0mg/kg for 14 days. At 36h (T1), 168h (T2) and 336h (T3) post-PH timepoints, a subgroup of six rats in each group was chosen in a randomized way to complementary hepatectomy (CH) and blood samples haversting. Collected material was saved for laboratory analysis (total bilirubin (TB), D-Glucose, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) and assessment of liver regeneration.

RESULTS:

TRT induced a significant decrease in liver and plasma GSH concentrations; liver regeneration process was not affected. TRT promoted a significant decrease in blood glucose levels 168h after partial hepatectomy compared with controls. TB levels remained unchanged.

CONCLUSION:

Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Oxidative Stress / Liver Regeneration Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFC/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Oxidative Stress / Liver Regeneration Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFC/BR