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Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study
Morgia, Giuseppe; Cimino, Sebastiano; Favilla, Vincenzo; Russo, Giorgio Ivan; Squadrito, Francesco; Mucciardi, Giuseppe; Masieri, Lorenzo; Minutoli, Letteria; Grosso, Giuseppe; Castelli, Tommaso.
  • Morgia, Giuseppe; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Cimino, Sebastiano; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Favilla, Vincenzo; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Russo, Giorgio Ivan; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Squadrito, Francesco; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Mucciardi, Giuseppe; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Masieri, Lorenzo; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Minutoli, Letteria; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Grosso, Giuseppe; University of Catania. Department of Hygiene and Public Health. Department of Urology.
  • Castelli, Tommaso; University of Catania. Department of Hygiene and Public Health. Department of Urology.
Int. braz. j. urol ; 39(2): 214-221, Mar-Apr/2013. tab, graf
Article in English | LILACS | ID: lil-676271
ABSTRACT
Objective To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). Materials and Methods We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated with BPH and high grade PIN and/or ASAP, randomly assigned to 11 ratio to daily Profluss® (group I) for 6 months or to control group (group Ic). Second group consisted of 60 subjects, with histological diagnosis of BPH, randomly assigned to 11 ratio to daily Profluss® + α-blockers treatment (group II) for 3 months or to control group (group IIc). After 6 months first group underwent 24 cores prostatic re-biopsy + 2 cores for PCI while after 3 months second group underwent two-cores prostatic for PCI. Specimens were evaluated for changes in inflammation parameters and for density of T-cells (CD3, CD8), B-cells (CD20) and macrophages (CD68). Results At follow-up there were statistical significant reductions of extension and grading of flogosis, mean values of CD20, CD3, CD68 and mean PSA value in group I compared to Ic, while extension and grading of flogosis in group II were inferior to IIc but not statistical significant. A statistically significant reduction in the density of CD20, CD3, CD68, CD8 was demonstrated in group II in respect to control IIc. Conclusions Serenoa repens+Selenium+Lycopene may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH and/or PIN/ASAP patients. .
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Full text: Available Index: LILACS (Americas) Main subject: Prostatic Hyperplasia / Prostatitis / Selenium / Plant Extracts / Carotenoids / Serenoa Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2013 Type: Article Affiliation country: Italy

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Full text: Available Index: LILACS (Americas) Main subject: Prostatic Hyperplasia / Prostatitis / Selenium / Plant Extracts / Carotenoids / Serenoa Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2013 Type: Article Affiliation country: Italy