Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study
Int. braz. j. urol
; 39(2): 214-221, Mar-Apr/2013. tab, graf
Article
in En
| LILACS
| ID: lil-676271
Responsible library:
BR1.1
ABSTRACT
Objective To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). Materials and Methods We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated with BPH and high grade PIN and/or ASAP, randomly assigned to 11 ratio to daily Profluss® (group I) for 6 months or to control group (group Ic). Second group consisted of 60 subjects, with histological diagnosis of BPH, randomly assigned to 11 ratio to daily Profluss® + α-blockers treatment (group II) for 3 months or to control group (group IIc). After 6 months first group underwent 24 cores prostatic re-biopsy + 2 cores for PCI while after 3 months second group underwent two-cores prostatic for PCI. Specimens were evaluated for changes in inflammation parameters and for density of T-cells (CD3, CD8), B-cells (CD20) and macrophages (CD68). Results At follow-up there were statistical significant reductions of extension and grading of flogosis, mean values of CD20, CD3, CD68 and mean PSA value in group I compared to Ic, while extension and grading of flogosis in group II were inferior to IIc but not statistical significant. A statistically significant reduction in the density of CD20, CD3, CD68, CD8 was demonstrated in group II in respect to control IIc. Conclusions Serenoa repens+Selenium+Lycopene may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH and/or PIN/ASAP patients. .
Key words
Full text:
1
Index:
LILACS
Main subject:
Prostatic Hyperplasia
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Prostatitis
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Selenium
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Plant Extracts
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Carotenoids
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Serenoa
Type of study:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Aged
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Humans
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Male
Country/Region as subject:
Europa
Language:
En
Journal:
Int Braz J Urol
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Int. braz j urol (Online)
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Int. braz. j. urol
/
International braz j urol (Impresso)
/
International brazilian journal of urology
Journal subject:
UROLOGIA
Year:
2013
Type:
Article