Biologically active compounds from cyanobacteria extracts: in vivo and in vitro aspects
Rev. bras. farmacogn
; 23(3): 471-480, May-June 2013. ilus, tab
Article
in En
| LILACS
| ID: lil-676287
Responsible library:
BR1.1
ABSTRACT
An investigation was directed towards the antiacetylcholinesterase activity of the acid aqueous and methanolic extracts of five cyanobacterial taxa, which encompasses an enzymatic inhibition essay and the evaluation of the physiological responses of mice to cyanobacterial extracts along with toxicological observations. The strains Calothrix sp. CCIBt 3320, Tolypothrix sp. CCIBt 3321, Phormidium cf. amoenum CCIBt 3412, Phormidium sp. CCIBt 3265, and Geitlerinema splendidum CCIBt 3223 were from the São Paulo Botanical Institute Cyanobacterial Culture Collection and all of them showed inhibitory effect on acetylcholinesterase activity (in vitro) and caused systemic effects similar to those described for anticholinesterase drugs (in vivo). With the exception of G. splendidum and Tolypothrix sp. strains, all extracts produced reversible antiacetylcolinesterase effects in mice. Complementary histopathological studies were carried out on tissues from animals administered with Phormidium sp. and P. cf. amoenum.
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Index:
LILACS
Language:
En
Journal:
Rev. bras. farmacogn
Journal subject:
FARMACIA
Year:
2013
Type:
Article