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Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer
Teixeira, Daniela; Almeida, Joaquim Soares de; Visniauskas, Bruna; Gomes, Guiomar Nascimento; Hirata, Aparecida Emiko; Bueno, Valquiria.
  • Teixeira, Daniela; Federal University of São Paulo. Immunology Division. São Paulo. BR
  • Almeida, Joaquim Soares de; Federal University of São Paulo. Immunology Division. São Paulo. BR
  • Visniauskas, Bruna; Federal University of São Paulo. Immunology Division. São Paulo. BR
  • Gomes, Guiomar Nascimento; Federal University of São Paulo. Immunology Division. São Paulo. BR
  • Hirata, Aparecida Emiko; Federal University of São Paulo. Immunology Division. São Paulo. BR
  • Bueno, Valquiria; Federal University of São Paulo. Immunology Division. São Paulo. BR
Clinics ; 68(6): 858-864, jun. 2013. tab, graf
Article in English | LILACS | ID: lil-676929
ABSTRACT

OBJECTIVES:

Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy. Identifying myeloid-derived suppressor cells and associated factors is the first step in creating strategies to reverse the suppressive effects of these cells on the immune system.

METHODS:

To induce lung cancer, we administered 2 doses of urethane to BALB/c mice and observed these animals for 120 days. After this period, we evaluated the percentage of myeloid-derived suppressor cells in the blood, lung and bone marrow. The expression of alpha-smooth muscle actin, transforming growth factor-β, Toll-like receptor 2, Toll-like receptor 4, and interleukin-6 was also determined in the lung tissue.

RESULTS:

Myeloid-derived suppressor cells were increased in all evaluated tissues after lung cancer development in association with increased Toll-like receptor 4 expression and decreased interleukin-6 expression in the lung. We observed alpha-smooth muscle actin and transforming growth factor-β expression in lung nodules.

CONCLUSIONS:

We believe that the early diagnosis of cancer through determining the blood levels of myeloid-derived suppressor cells followed by the depletion of these cells should be further investigated as a possible approach for cancer treatment. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Myeloid Cells / Lung Neoplasms Type of study: Prognostic study / Risk factors / Screening study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Myeloid Cells / Lung Neoplasms Type of study: Prognostic study / Risk factors / Screening study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR