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Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke
Valenti, Vitor E.; Abreu, Luiz Carlos de; Fonseca, Fernando L. A.; Adami, Fernando; Sato, Monica A.; Vanderlei, Luiz Carlos M.; Ferreira, Lucas Lima; Rodrigues, Luciano M.; Ferreira, Celso.
  • Valenti, Vitor E.; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Abreu, Luiz Carlos de; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Fonseca, Fernando L. A.; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Adami, Fernando; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Sato, Monica A.; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Vanderlei, Luiz Carlos M.; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Ferreira, Lucas Lima; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Rodrigues, Luciano M.; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
  • Ferreira, Celso; Universidade Estadual Paulista. Faculdade de Ciências e Tecnologia. Presidente Prudente. BR
Clinics ; 68(6): 851-857, jun. 2013. tab
Article in English | LILACS | ID: lil-676947
ABSTRACT

OBJECTIVE:

Previous studies have demonstrated a relationship between brain oxidative stress and cardiovascular regulation. We evaluated the effects of central catalase inhibition on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke.

METHODS:

Male Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SH) (16 weeks old) were implanted with a stainless steel guide cannula leading into the fourth cerebral ventricle (4th V). The femoral artery and vein were cannulated for arterial pressure and heart rate measurement and drug infusion, respectively. The rats were exposed to sidestream cigarette smoke for 180 minutes/day, 5 days/week for 3 weeks (CO 100-300 ppm). The baroreflex was tested using a pressor dose of phenylephrine (8 μg/kg, bolus) and a depressor dose of sodium nitroprusside (50 μg/kg, bolus). Cardiovascular responses were evaluated before and 5, 15, 30 and 60 minutes after injection of a catalase inhibitor (3-amino-1,2,4-triazole, 0.001 g/100 μL) into the 4th V.

RESULTS:

Vehicle administration into the 4th V did not affect the cardiovascular response, whereas administration of the central catalase inhibitor increased the basal HR and attenuated the bradycardic peak (p<0.05) to a greater extent in WKY rats exposed to sidestream cigarette smoke than in WKY rats exposed to fresh air. However, in spontaneously hypertensive rats, the effect of the catalase inhibitor treatment was stronger in the fresh air condition (p<0.05).

CONCLUSION:

Administration of a catalase inhibitor into the 4th V combined with exposure to sidestream cigarette smoke has a stronger effect in WKY rats than in SH rats. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tobacco Smoke Pollution / Cardiovascular System / Catalase / Fourth Ventricle / Enzyme Inhibitors / Amitrole Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tobacco Smoke Pollution / Cardiovascular System / Catalase / Fourth Ventricle / Enzyme Inhibitors / Amitrole Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR