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Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil
Memórias do Instituto Oswaldo Cruz; Marx, Camila; Gregianini, Tatiana Schäffer; Lehmann, Fernanda Kieling Moreira; Lunge, Vagner Ricardo; Carli, Silvia de; Dambrós, Bibiana Paula; Tumioto, Gabriela Luchiari; Seadi, Claudete; Fonseca, André Salvador Kazantzi; Ikuta, Nilo.
  • Marx, Camila; Universidade Luterana do Brasil. Canoas. BR
  • Gregianini, Tatiana Schäffer; Universidade Luterana do Brasil. Canoas. BR
  • Lehmann, Fernanda Kieling Moreira; Universidade Luterana do Brasil. Canoas. BR
  • Lunge, Vagner Ricardo; Universidade Luterana do Brasil. Canoas. BR
  • Carli, Silvia de; Universidade Luterana do Brasil. Canoas. BR
  • Dambrós, Bibiana Paula; Universidade Luterana do Brasil. Canoas. BR
  • Tumioto, Gabriela Luchiari; Universidade Luterana do Brasil. Canoas. BR
  • Seadi, Claudete; Universidade Luterana do Brasil. Canoas. BR
  • Fonseca, André Salvador Kazantzi; Universidade Luterana do Brasil. Canoas. BR
  • Ikuta, Nilo; Universidade Luterana do Brasil. Canoas. BR
Mem. Inst. Oswaldo Cruz ; 108(3): 392-394, maio 2013.
Article in English | LILACS | ID: lil-676978
Responsible library: BR1.1
ABSTRACT
The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Drug Resistance, Viral / Influenza A Virus, H1N1 Subtype / Oseltamivir / Mutation / Neuraminidase Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2013 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Luterana do Brasil/BR

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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Drug Resistance, Viral / Influenza A Virus, H1N1 Subtype / Oseltamivir / Mutation / Neuraminidase Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2013 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Luterana do Brasil/BR