Effect of copaiba oil in hepatic damage induced by acetaminophen in rats
Acta cir. bras
;
28(7): 526-530, July 2013. tab
Article
in English
| LILACS
| ID: lil-679085
ABSTRACT
PURPOSE:
To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.METHODS:
Thirty six rats were distributed into six study groups (N=6) control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase,![](../img/a08img01.jpg)
RESULTS:
The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and![](../img/a08img01.jpg)
CONCLUSION:
Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plant Oils
/
Analgesics, Non-Narcotic
/
Chemical and Drug Induced Liver Injury
/
Fabaceae
/
Acetaminophen
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFPA/BR
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