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Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats
Müzell, Denise Pereira; Lunardelli, Adroaldo; Leite, Carlos Eduardo; Fagundes, Rodrigo Medeiros; Saciura, Vasyl Custódio; Reichel, Carlos Luiz; Oliveira, Jarbas Rodrigues de; Astarita, Leandro Vieira.
  • Müzell, Denise Pereira; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Lunardelli, Adroaldo; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Leite, Carlos Eduardo; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Fagundes, Rodrigo Medeiros; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Saciura, Vasyl Custódio; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Reichel, Carlos Luiz; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Oliveira, Jarbas Rodrigues de; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
  • Astarita, Leandro Vieira; Pontifícia Universidade Católica do Rio Grande do Sul. Laboratório de Anatomia Patológica. Porto Alegre. BR
Braz. arch. biol. technol ; 56(3): 383-392, May-June 2013. ilus, tab
Article in English | LILACS | ID: lil-679185
ABSTRACT
This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results suggested that the extract was not hepatoprotective and could lead to an increase in the lesions induced by the APAP. On the other hand, the extract was nephroprotective against the lesions induced by the APAP and showed an anti-inflammatory effect on pleurisy carrageenan-induced.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR