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Effects of propofol on damage of rat intestinal epithelial cells induced by heat stress and lipopolysaccharides
Brazilian Journal of Medical and Biological Research; Tang, J.; Jiang, Y.; Tang, Y.; Chen, B.; Sun, X.; Su, L.; Liu, Z..
  • Tang, J.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Jiang, Y.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Tang, Y.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Chen, B.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Sun, X.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Su, L.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
  • Liu, Z.; Southern Medical University. Nanfang Hospital. Department of Anesthesia. Guangzhou. CN
Braz. j. med. biol. res ; 46(6): 507-512, 02/jul. 2013. graf
Article in English | LILACS | ID: lil-679207
ABSTRACT
Gut-derived endotoxin and pathogenic bacteria have been proposed as important causative factors of morbidity and death during heat stroke. However, it is still unclear what kind of damage is induced by heat stress. In this study, the rat intestinal epithelial cell line (IEC-6) was treated with heat stress or a combination of heat stress and lipopolysaccharide (LPS). In addition, propofol, which plays an important role in anti-inflammation and organ protection, was applied to study its effects on cellular viability and apoptosis. Heat stress, LPS, or heat stress combined with LPS stimulation can all cause intestinal epithelial cell damage, including early apoptosis and subsequent necrosis. However, propofol can alleviate injuries caused by heat stress, LPS, or the combination of heat stress and LPS. Interestingly, propofol can only mitigate LPS-induced intestinal epithelial cell apoptosis, and has no protective role in heat-stress-induced apoptosis. This study developed a model that can mimic the intestinal heat stress environment. It demonstrates the effects on intestinal epithelial cell damage, and indicated that propofol could be used as a therapeutic drug for the treatment of heat-stress-induced intestinal injuries.
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Full text: Available Index: LILACS (Americas) Main subject: Propofol / Anesthetics, Intravenous / Heat Stroke / Epithelial Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Southern Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Propofol / Anesthetics, Intravenous / Heat Stroke / Epithelial Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Southern Medical University/CN