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Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
Padovani, Cacilda Tezelli Junqueira; Bonin, Camila Mareti; Tozetti, Ines Aparecida; Ferreira, Alda Maria Teixeira; Fernandes, Carlos Eurico dos Santos; Costa, Izaias Pereira da.
  • Padovani, Cacilda Tezelli Junqueira; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
  • Bonin, Camila Mareti; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
  • Tozetti, Ines Aparecida; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
  • Ferreira, Alda Maria Teixeira; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
  • Fernandes, Carlos Eurico dos Santos; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
  • Costa, Izaias Pereira da; Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pos-Graduacao em Saude e Desenvolvimento da Regiao Centro-Oeste. Campo Grande. BR
Rev. Soc. Bras. Med. Trop ; 46(3): 288-292, May-Jun/2013. tab, graf
Article in English | LILACS | ID: lil-679528
ABSTRACT
Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. .
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Full text: Available Index: LILACS (Americas) Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / Glucocorticoid-Induced TNFR-Related Protein Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Mato Grosso do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / Glucocorticoid-Induced TNFR-Related Protein Limits: Adult / Female / Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Mato Grosso do Sul/BR