Agregados amiloides: rol en desórdenes de conformación proteica / Amyloid aggregates: role in protein misfolding disorders
Rev. méd. Chile
;
141(4): 495-505, abr. 2013. ilus
Article
in Spanish
| LILACS
| ID: lil-680473
ABSTRACT
Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Neurodegenerative Diseases
/
Proteostasis Deficiencies
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
University of Texas Medical School at Houston/US
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