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Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder
Revista Brasileira de Psiquiatria; Chiarani, Fabria; Tramontina, Juliana Fernandes; Cereser, Keila Maria; Kunz, Mauricio; Paim, Leonardo; Vargas, Carmen Regla; Sitta, Angela; Machado, Sergio Pinto; Wyse, Angela Terezinha de Souza; Kapczinski, Flavio Pereira.
  • Chiarani, Fabria; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Tramontina, Juliana Fernandes; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Cereser, Keila Maria; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Kunz, Mauricio; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Paim, Leonardo; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Vargas, Carmen Regla; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Sitta, Angela; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Machado, Sergio Pinto; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Wyse, Angela Terezinha de Souza; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
  • Kapczinski, Flavio Pereira; Universidade Federal do Rio Grande do Sul (UFRGS). Hospital de Clinicas de Porto Alegre (HCPA). Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM). Porto Alegre. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 35(2): 157-160, April-June 2013. tab
Article in English | LILACS | ID: lil-680895
ABSTRACT

Objective:

To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls.

Methods:

The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP).

Results:

Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP.

Conclusions:

These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Cardiovascular Diseases / Homocysteine Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul (UFRGS)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Cardiovascular Diseases / Homocysteine Type of study: Etiology study / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul (UFRGS)/BR