Red blood cell and leukocyte alloimmunization in patients awaiting kidney transplantation
Rev. bras. hematol. hemoter
;
35(3): 185-188, jun. 2013. tab
Article
in English
| LILACS
| ID: lil-681968
ABSTRACT
Objective:
To determine the rates of red blood cell and leukocyte alloimmunization in patients with chronic kidney disease awaiting kidney transplantation.Methods:
In this cross-sectional and prospective study, the serum of 393 chronic kidney disease patients on a transplant waiting list in Ceará, Northeastern Brazil were tested for red cell and leukocyte antibodies. In addition, demographic, clinical and laboratory data were collected.Results:
The average age in the sample of 393 patients was 34.1 ± 14 years. Slightly more than half (208; 52.9%) were male. The average numbers of transfusions and gestations were 3.1 ± 3.3 and 1.6 ± 6, respectively. One third (33.6%) were alloimmunized 78% with leukocyte antibodies, 9.1% with red cell antibodies and 12.9% with both. Red cell antibodies were detected in 29 cases (7.4%), 17 of whom were women, who had received more transfusions than the males (p-value < 0.0001). The most frequently detected red cell antibodies belonged to the Rh (24.1%) and Kell (13.8%) blood group systems. Leukocyte antibodies were detected in 30.5% of cases, 83 of whom were women, who had received more transfusions than the males (p-value < 0.0001) and were more reactive to panel reactive antibodies (p-value < 0.0001). The mean alloreactivity to panel reactive antibodies was 47.7 ± 31.2%.Conclusion:
Chronic kidney disease patients on the transplant waiting list in Ceará, Brazil, display high ...
Full text:
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Index:
LILACS (Americas)
Main subject:
Blood Transfusion
/
Cross-Sectional Studies
/
Kidney Transplantation
/
Erythrocyte Transfusion
/
Renal Insufficiency
/
Kidney Failure, Chronic
/
Antibodies
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Fortaleza/BR
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