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An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice
Brazilian Journal of Medical and Biological Research; Magro, D.A.C.; Hohmann, M.S.N.; Mizokami, S.S.; Cunha, T.M.; Alves-Filho, J.C.; Casagrande, R.; Ferreira, S.H.; Liew, F.Y.; Cunha, F.Q.; Verri Jr, W.A..
  • Magro, D.A.C.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Hohmann, M.S.N.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Mizokami, S.S.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Cunha, T.M.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Alves-Filho, J.C.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Casagrande, R.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Ferreira, S.H.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Liew, F.Y.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Cunha, F.Q.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
  • Verri Jr, W.A.; Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto. BR
Braz. j. med. biol. res ; 46(7): 601-606, ago. 2013. graf
Article in English | LILACS | ID: lil-682395
ABSTRACT
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.
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Full text: Available Index: LILACS (Americas) Main subject: Pain Measurement / Signal Transduction / Interleukins / Receptors, Interleukin / Nociceptive Pain / Hyperalgesia Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pain Measurement / Signal Transduction / Interleukins / Receptors, Interleukin / Nociceptive Pain / Hyperalgesia Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR