DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
Biol. Res
;
46(2): 161-167, 2013. tab
Article
in English
| LILACS
| ID: lil-683993
ABSTRACT
DNA repair is one of the central defense mechanisms against mutagenic exposures. Inherited SNPs of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. Saudi Arabia harbors enormous genetic and cultural diversity. In the present study we aimed to determine the genotype and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 386 healthy individuals residing in the central region of Saudi Arabia and compare them with HapMap and other populations. The genotype and allele frequencies of the four DNA repair gene loci in central Saudi population showed a distinctive pattern. Furthermore, comparison of polymorphisms in these genes with other populations also showed a unique pattern for the central Saudi population. To the best of our knowledge, this is the first report that deals with these DNA repair gene polymorphisms among the central Saudi population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Single Nucleotide
/
DNA Glycosylases
/
DNA-Binding Proteins
/
DNA Repair
/
Xeroderma Pigmentosum Group D Protein
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Saudi Arabia
Institution/Affiliation country:
King Saud University/SA
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