Aumento de interleuquinas proinflamatorias y de cortisol plasmático en bronquiolitis por virus respiratorio sincicial: relación con la gravedad de la infección / Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
Rev. méd. Chile
;
141(5): 574-581, mayo 2013. graf, tab
Article
in Spanish
| LILACS
| ID: lil-684364
ABSTRACT
Background:
An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection.Aim:
To quantify pro-inflammatory cytokines (IL-6-IL-8, ÍL-2-P and TNF-a) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients andMethods:
We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis.Results:
Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels ofIL-6 and IL-8 in NPA and plasma and IL-lfi in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease.Conclusions:
RSV bronchiolitis severity was associated with higher levéis of inflammatory interleukins and plasma cortisol.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hydrocortisone
/
Bronchiolitis
/
Interleukins
/
Tumor Necrosis Factor-alpha
/
Respiratory Syncytial Virus Infections
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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