Evidencia que soporta el uso de la terapia combinada en el tratamiento de la hipertensión arterial / Evidence supporting the use of combination therapy in the treatment of hypertension

ABSTRACT

With the current knowledge of hypertension, the understanding of the pathophysiological mechanisms of hypertensionhasadvanced, where the main actors are the renin angiotensin aldosterone system and the sympathetic system. However,we are still far from understanding the complex interplay of these compensatory mechanisms and the behavior of bloodpressure. Today we know from various studies of hypertension, that 60 to 80% of the patients will require combinedtherapy for an adequate control of blood pressure numbers.