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Immediate graft histological assay, post pig's liver transplantation
Brito, Marcus Vinicius Henriques; Araújo, Marialva Tereza Ferreira de; Cunha, Luane Cristine Batista; Oliveira, Antônio Jorge Barbosa de; Rodrigues, Jacqueline Barreto; Brito, Nathalya Botelho.
  • Brito, Marcus Vinicius Henriques; Para State University. Medical School. Department of Integrate Health.
  • Araújo, Marialva Tereza Ferreira de; Para State University. Medical School. Department of Integrate Health.
  • Cunha, Luane Cristine Batista; Para State University. Medical School. Department of Integrate Health.
  • Oliveira, Antônio Jorge Barbosa de; Para State University. Medical School. Department of Integrate Health.
  • Rodrigues, Jacqueline Barreto; Para State University. Medical School. Department of Integrate Health.
  • Brito, Nathalya Botelho; Para State University. Medical School. Department of Integrate Health.
Acta cir. bras ; 28(9): 678-682, Sept. 2013. ilus
Article in English | LILACS | ID: lil-684443
ABSTRACT

PURPOSE:

To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs.

METHODS:

Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3.

RESULTS:

Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7.

CONCLUSIONS:

The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Liver Transplantation / Liver Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil

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Full text: Available Index: LILACS (Americas) Main subject: Liver Transplantation / Liver Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil