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Epidemiological and histopathological profile of cutaneous melanoma at a center in northeastern Brazil from 2000 to 2010 / Perfil epidemiologico e histopatologico do melanoma cutaneo em um centro do nordeste brasileiro de 2000 a 2010
Vilanova, Camila Maria Arruda; Lages, Rafael Bandeira; Ribeiro, Sahamia Martins; Almeida, Isabella Parente; Santos, Lina Gomes dos; Vieira, Sabas Carlos.
  • Vilanova, Camila Maria Arruda; s.af
  • Lages, Rafael Bandeira; s.af
  • Ribeiro, Sahamia Martins; s.af
  • Almeida, Isabella Parente; s.af
  • Santos, Lina Gomes dos; s.af
  • Vieira, Sabas Carlos; s.af
An. bras. dermatol ; 88(4): 545-553, ago. 2013. tab, graf
Article in English | LILACS | ID: lil-686513
ABSTRACT
BACKGROUND: While representing only 3-4% of malignant skin tumors, cutaneous melanoma is the most aggressive and lethal. Statistical knowledge about the biological behavior of this tumor is essential for guiding daily outpatient practice and aiding public health policies. OBJECTIVES: To analyze the profile of patients with cutaneous melanoma attending a pathology department in Teresina (state of Piauí) between 2000 and 2010. METHODS: Retrospective study of melanoma patients diagnosed between 2000 and 2010 in the São Marcos Hospital in the city of Teresina. The pathology laboratory reports were studied and all the statistical analyses performed using SPSS 19.0. RESULTS: A total of 25 in situ, 199 invasive and 89 metastatic melanomas of unknown primary site were observed. Histological types found were nodular (52.8%), superficial spreading melanoma (18.6%), acral (10.6%) and lentigo maligna (9.5%). In 144 (73.4%) cases the Breslow thickness was >1 mm. Metastasis was found in 28.6% of invasive melanomas and nodular melanoma, Clark IV/ V, Breslow > 1 mm, mitotic index > 6 and ulcerated lesions were more likely to metastasize. CONCLUSION: Most melanomas presented Breslow> 1mm. The main factors associated with metastasis were nodular type, Clark IV / V, Breslow> 1mm, mitotic index > 6 and ulcerated lesions. .
RESUMO
FUNDAMENTOS: Apesar de representar apenas 3-4% dos tumores malignos de pele, o melanoma cutâneo é o mais agressivo e letal deles. O conhecimento estatístico do comportamento biológico deste tumor em nosso meio ambiente é fundamental para orientar a prática ambulatorial diária e para auxiliar políticas de saúde pública. OBJETIVOS: Analisar o perfil de pacientes com melanoma cutâneo diagnosticados em serviço de referência em patologia em Teresina-Piauí no período de 2000 a 2010. MÉTODOS: Estudo retrospectivo de pacientes com melanoma diagnosticados entre 2000 e 2010 no Hospital São Marcos, Teresina-Piauí-Brasil. Estudou-se laudos histopatológicos e realizou-se análises estatísticas com o programa SPSS 19,0. RESULTADOS: Um total de 25 melanomas in situ, 199 invasivos e 89 metastáticos de sítio primário desconhecido foram observados. Tipos histológicos encontrados foram nodular (52,8%), melanoma extensivo superficial (18,6%), acral (10,6%) e lentigo maligno (9,5%). Em 144 (73,4%) casos o índice de Breslow foi >1 mm. Verificou-se metástases em 28,6% dos melanomas invasivos e melanoma nodular, Clark IV/V, Breslow >1 mm, índice mitótico ≥6 e lesões ulceradas estavam mais propensos a metástases. CONCLUSÃO: Melanomas com Breslow >1mm foram os casos predominantes. Principais fatores ...
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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Melanoma Type of study: Observational study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2013 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Melanoma Type of study: Observational study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2013 Type: Article