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Nitro-fatty acids: novel anti-inflammatory lipid mediators
Rubbo, H..
Affiliation
  • Rubbo, H.; s.af
Braz. j. med. biol. res ; 46(9): 735-738, 19/set. 2013. graf
Article in En | LILACS | ID: lil-686579
Responsible library: BR1.1
ABSTRACT
Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.
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Full text: 1 Index: LILACS Main subject: Signal Transduction / Arachidonic Acid / Fatty Acids / Anti-Inflammatory Agents / Nitric Oxide / Nitro Compounds Limits: Humans Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2013 Type: Article

Full text: 1 Index: LILACS Main subject: Signal Transduction / Arachidonic Acid / Fatty Acids / Anti-Inflammatory Agents / Nitric Oxide / Nitro Compounds Limits: Humans Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2013 Type: Article