Nitro-fatty acids: novel anti-inflammatory lipid mediators
Braz. j. med. biol. res
; 46(9): 735-738, 19/set. 2013. graf
Article
in En
| LILACS
| ID: lil-686579
Responsible library:
BR1.1
ABSTRACT
Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.
Key words
Full text:
1
Index:
LILACS
Main subject:
Signal Transduction
/
Arachidonic Acid
/
Fatty Acids
/
Anti-Inflammatory Agents
/
Nitric Oxide
/
Nitro Compounds
Limits:
Humans
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2013
Type:
Article