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Poly (Methyl Methacrylate) absorption and releasing of nystatin and fluconazole / Absorção e liberação de nistatina e fluconazol por polimetilmetacrilato
Silva, Wander José da; Gonçalves, Letícia Machado; Faot, Fernanda; Trevizan, Luiz Roberto Pimentel; Del Bel Cury, Altair Antoninha.
  • Silva, Wander José da; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontology. Piracicaba. BR
  • Gonçalves, Letícia Machado; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontology. Piracicaba. BR
  • Faot, Fernanda; Federal University of Pelotas. Dental School. Department of Restorative Dentistry. Pelotas. BR
  • Trevizan, Luiz Roberto Pimentel; University of São Paulo. College of Agriculture Luiz de Queiroz. Department of Entomology. Piracicaba. BR
  • Del Bel Cury, Altair Antoninha; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontology. Piracicaba. BR
Arch. oral res. (Impr.) ; 7(3): 259-266, Sept.-Dec. 2011.
Article in English | LILACS, BBO | ID: lil-687439
ABSTRACT

Objectives:

The aim of this study was to verify if there are poly (methyl methacrylate) (PMMA) absorptionand releasing of nystatin (NYS) and fluconazole (FLZ) after simulated treatment of oral candidosis. Materialsand

methods:

Specimens (30 × 25 × 5 mm) prepared with PMMA polymerized by hot water bath or microwaveenergy were immersed into NYS (3.12 μg/mL), FLZ (2.56 μg/mL) or deionized water (control) during14 days at 35 ± 2 °C. After treatment simulation, specimens were immersed into distilled water during 3, 7, 10and 14 days. The immersion liquid was changed after each analysis. Higher performance liquid chromatographywas used in order to detect antifungal compounds. In order to determine if there was surface depositionof drugs on PMMA resin, specimens were analyzed with electronic microscopy (SEM).

Results:

None of theantifungal agents was released from the PMMA resins.

Conclusion:

Within the limitations of this study, itcould be concluded that PMMA resins had no drug absorption with posterior release.
RESUMO

Objetivos:

O objetivo deste estudo foi verificar se o poli (metil metacrilato) (PMMA) é capaz de absorver e liberar nistatina (NYS) e fluconazol (FLZ) após simular um tratamento para candidose oral.

Materiais e métodos:

Espécimes (30 × 25 × 5 mm) foram preparados em resina de PMMA por banho de água quente ou energia demicro-ondas e, em seguida, imersos em solução contendo NYS (3.12 μg/mL), FLZ (2.56 μg/mL) ou água deionizada(controle) durante 14 dias a 35 ± 2 °C. Após a simulação de tratamento, os espécimes foram imersos em água destilada durante 3, 7, 10 e 14 dias. O líquido de imersão foi trocado após cada análise. Cromatografia líquida de alta performance foi utilizada para detectar a presença dos agentes antifúngicos. Para determinar se houve deposição dos agentes antifúngicos na superfície de PMMA, os espécimes foram analisados por microscopia eletrônica de varredura(MEV).

Resultados:

Não houve liberação de agentes antifúngicos dos espécimes.

Conclusão:

Considerando as limitações deste estudo, pode-se concluir que a resina de PMMA não absorve ou libera agentes antifúngicos.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Fluconazole / Nystatin / Polymethyl Methacrylate / Antifungal Agents Language: English Journal: Arch. oral res. (Impr.) Journal subject: Dentistry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pelotas/BR / University of Campinas/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fluconazole / Nystatin / Polymethyl Methacrylate / Antifungal Agents Language: English Journal: Arch. oral res. (Impr.) Journal subject: Dentistry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pelotas/BR / University of Campinas/BR / University of São Paulo/BR