Evaluation of lipoic acid topical application on rats skin wound healing
Acta cir. bras
;
28(10): 708-715, Oct. 2013. ilus, tab
Article
in English
| LILACS
| ID: lil-687744
ABSTRACT
PURPOSE:
To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process.METHODS:
The model used was the healing activity on wounds induced by surgical incision on rats skin (n = 44). The parameters analyzed (11 days) were wound healing rate and histology (vascular proliferation, polymorphonuclear or mononuclear cells, and collagen synthesis or reepithelialization), after application of free lipoic acid or lipoic acid- loaded nanocapsules. The antioxidant activity of these formulations was evaluated by lipid peroxidation test.RESULTS:
It was demonstrated for the first time that the topical application of lipoic acid improves wound healing. On the seventh day after surgery, the animals treated with lipoic acid showed increased healing rate (60.7 ± 8.4%) compared to the negative control group (43.0 ± 17.4%), as so improvement of histological parameters. The nanoencapsulation reverted the pro-oxidant activity presented in vitro by lipoic acid, whereas diminished wound repair.CONCLUSIONS:
The topical application of lipoic acid produced an increase in the skin wound healing, which may be related to its pro-oxidant activity. On the other hand, the nanoencapsulation of the lipoic acid reversed the pro-oxidant activity, although presented minor healing activity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Skin
/
Wound Healing
/
Thioctic Acid
/
Nanocapsules
/
Antioxidants
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio Grande do Sul/BR
Similar
MEDLINE
...
LILACS
LIS