Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
35(3): 262-266, Jul-Sep. 2013. graf
Article
in English
| LILACS
| ID: lil-687934
ABSTRACT
Objective:
To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days.Method:
Behavioral evaluation was undertaken at 1 and 6 hours after the last injection.Results:
We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection.Conclusion:
These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain
/
Brain-Derived Neurotrophic Factor
/
Ketamine
/
Anesthetics, Dissociative
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
National Science and Technology Institute for Translational Medicine/BR
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