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Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Borges, F.T.; Reis, L.A.; Schor, N..
  • Borges, F.T.; Universidade Federal Paulista. Escola Paulista de Medicina. Departamento de Medicina. Divisao de Nefrologia. Sao Paulo. BR
  • Reis, L.A.; Universidade Federal Paulista. Escola Paulista de Medicina. Departamento de Medicina. Divisao de Nefrologia. Sao Paulo. BR
  • Schor, N.; Universidade Federal Paulista. Escola Paulista de Medicina. Departamento de Medicina. Divisao de Nefrologia. Sao Paulo. BR
Braz. j. med. biol. res ; 46(10): 824-830, 24/set. 2013. tab, graf
Article in English | LILACS | ID: lil-688561
Responsible library: BR1.1
ABSTRACT
Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.
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Full text: Available Index: LILACS (Americas) Main subject: Cell Communication / Cell Membrane / Exosomes / Kidney Diseases Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cell Communication / Cell Membrane / Exosomes / Kidney Diseases Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Paulista/BR