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Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
Antonello, Vicente Sperb; Appel-da-Silva, Marcelo Campos; Kliemann, Dimas Alexandre; Santos, Breno Riegel; Tovo, Cristiane Valle.
  • Antonello, Vicente Sperb; Hospital Fêmina. Department of Infection Control. Porto Alegre. BR
  • Appel-da-Silva, Marcelo Campos; Hospital Fêmina. Department of Infection Control. Porto Alegre. BR
  • Kliemann, Dimas Alexandre; Hospital Fêmina. Department of Infection Control. Porto Alegre. BR
  • Santos, Breno Riegel; Hospital Fêmina. Department of Infection Control. Porto Alegre. BR
  • Tovo, Cristiane Valle; Hospital Fêmina. Department of Infection Control. Porto Alegre. BR
Braz. j. infect. dis ; 17(5): 551-554, Sept.-Oct. 2013. ilus, tab
Article in English | LILACS | ID: lil-689880
ABSTRACT

OBJECTIVE:

To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients.

METHODS:

The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48.

RESULTS:

There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 Tlymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups.

CONCLUSION:

This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / Hepatitis C / Antiretroviral Therapy, Highly Active / Coinfection Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Fêmina/BR

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Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / Hepatitis C / Antiretroviral Therapy, Highly Active / Coinfection Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Fêmina/BR