PTK2 and PTPN11 expression in myelodysplastic syndromes
Clinics
;
68(10): 1371-1375, out. 2013. tab, graf
Article
in English
| LILACS
| ID: lil-689980
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes.METHODS:
Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors.RESULTS:
Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells.CONCLUSIONS:
Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Myelodysplastic Syndromes
/
Bone Marrow Cells
Type of study:
Etiology study
/
Evaluation studies
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hemocentro-Unicamp+BR
Similar
MEDLINE
...
LILACS
LIS