Animal models of neurodegenerative diseases
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
35(supl.2): S82-S91, 2013. graf
Article
in English
| LILACS
| ID: lil-691406
ABSTRACT
The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progression. Animal models contribute to increase the knowledge on the pathophysiology of neurodegenerative diseases. These models reproduce different aspects of a given disease, as well as the histopathological lesions and its main symptoms. The purpose of this review is to present the main animal models for AD, PD, and Huntington's disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Parkinson Disease
/
Huntington Disease
/
Disease Models, Animal
/
Alzheimer Disease
Type of study:
Risk factors
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR
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