Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
Rev. Soc. Bras. Med. Trop
;
46(5): 645-649, Sept-Oct/2013. tab, graf
Article
in English
| LILACS
| ID: lil-691420
ABSTRACT
Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oxidative Stress
/
Glutathione
/
Leprosy
/
Nitric Oxide
/
Antioxidants
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Para/BR
Similar
MEDLINE
...
LILACS
LIS