Septin 7: Actin cross-organization is required for axonal association of Schwann cells
Biol. Res
;
46(3): 243-249, 2013. ilus, graf
Article
in English
| LILACS
| ID: lil-692190
ABSTRACT
Myelin sheaths present two distinct domains compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schwann Cells
/
Axons
/
Actins
/
Septins
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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