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Septin 7: Actin cross-organization is required for axonal association of Schwann cells
Roth, Alejandro D; Liazoghli, Dalinda; Perez De Arce, Felipe; Colman, David R.
  • Roth, Alejandro D; Universidad de Chile. Facultad de Ciencias. Departamento de Biología. Laboratorio de Biología Celular de Glias. Santiago. CL
  • Liazoghli, Dalinda; Universidad de Chile. Facultad de Ciencias. Departamento de Biología. Laboratorio de Biología Celular de Glias. Santiago. CL
  • Perez De Arce, Felipe; Universidad de Chile. Facultad de Ciencias. Departamento de Biología. Laboratorio de Biología Celular de Glias. Santiago. CL
  • Colman, David R; Universidad de Chile. Facultad de Ciencias. Departamento de Biología. Laboratorio de Biología Celular de Glias. Santiago. CL
Biol. Res ; 46(3): 243-249, 2013. ilus, graf
Article in English | LILACS | ID: lil-692190
ABSTRACT
Myelin sheaths present two distinct domains compacted myelin spirals and flanking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting GTPases, form intracellular diffusion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins, particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfilament but not microtubule organization.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Schwann Cells / Axons / Actins / Septins Type of study: Risk factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2013 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Schwann Cells / Axons / Actins / Septins Type of study: Risk factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2013 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL