Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects
Biol. Res
;
46(3): 265-273, 2013. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-692193
ABSTRACT
Purpose:
The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. Materials andMethods:
PubMed, Embase, CBM (China Biological Medicine Database), Wanfang and VIP databases were searched to identify eligible studies published in English and Chinese before March 2013. Data were extracted using standardized methods. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Begg's test was used to measure publication bias.Results:
A total of 40 case-control studies containing 16,518 EH patients and 20,284 controls were involved in this meta-analysis. Overall, a significant association was found between GNB3 C825T polymorphism and risk of EH when all studies were pooled with a random-effects model for T versus C (OR=1.09, 95% CI 1.04-1.19). In the subgroup analysis, the same association was found in overall Caucasian (T versus C, OR=1.16, 95% CI 1.08-1.24) and Chinese populations (TT versus CC, OR=1.23, 95% CI 1.06-1.57). No associations were detected between GNB3-C825T and the risk of EH overall in Asian and Japanese people.Conclusions:
Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese. The effect of the variants on the expression levels and the possible functional role of the variants in EH should be addressed in further studies.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Genetic Predisposition to Disease
/
Heterotrimeric GTP-Binding Proteins
/
Hypertension
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2013
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Tongji University/CN
Similar
MEDLINE
...
LILACS
LIS