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Aplastic anemia associated to systemic lupus erythematosus in an AIDS patient: a case report
Oliveira, Leonardo Rodrigues de; Ferreira, Thais Camargos; Neves, Fernando de Freitas; Meneses, Antonio Carlos de Oliveira.
  • Oliveira, Leonardo Rodrigues de; Universidade Federal do Triangulo Mineiro. Uberaba. BR
  • Ferreira, Thais Camargos; Universidade Federal do Triangulo Mineiro. Uberaba. BR
  • Neves, Fernando de Freitas; Universidade Federal do Triangulo Mineiro. Uberaba. BR
  • Meneses, Antonio Carlos de Oliveira; Universidade Federal do Triangulo Mineiro. Uberaba. BR
Rev. bras. hematol. hemoter ; 35(5): 366-368, 2013. graf
Article in English | LILACS | ID: lil-694079
ABSTRACT
Aplastic anemia is a bone marrow failure syndrome characterized by peripheral cytopenias and hypocellular bone marrow. Although aplastic anemia is idiopathic in most cases, rheumatic diseases such as systemic lupus erythematosus are recognized as causes of aplastic anemia, with their possible etiological mechanisms being T and B lymphocyte dysfunction and pro-inflammatory cytokines and autoantibody production directed against bone marrow components. In the course of the human immunodeficiency virus infection/acquired immunodeficiency syndrome, the identification of autoantibodies and the occurrence of rheumatic events, in addition to the natural course of systemic lupus erythematosus which is modified by immune changes that are characteristic of human immunodeficiency virus infection/acquired immunodeficiency syndrome, make the diagnosis of systemic lupus erythematosus challenging. This study reports the case of a woman with acquired immunodeficiency syndrome treated with a highly active antiretroviral therapy, who had prolonged cytopenias and hypocellular bone marrow consistent with aplastic anemia. The clinical picture, high autoantibodies titers, and sustained remission of the patient's hematological status through immunosuppression supported the diagnosis of systemic lupus erythematosus-associated aplastic anemia. This is the first report of aplastic anemia concurrent with systemic lupus erythematosus and acquired immunodeficiency syndrome, providing additional evidence that immune dysfunction is a key part of the pathophysiological mechanism of aplastic anemia.
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Full text: Available Index: LILACS (Americas) Main subject: Pancytopenia / Autoantibodies / HIV Infections / Acquired Immunodeficiency Syndrome / Anemia, Aplastic / Lupus Erythematosus, Systemic Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triangulo Mineiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pancytopenia / Autoantibodies / HIV Infections / Acquired Immunodeficiency Syndrome / Anemia, Aplastic / Lupus Erythematosus, Systemic Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triangulo Mineiro/BR