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Comparación entre CHOP-like y R-CHOP en pacientes con linfoma no Hodgkin difuso de grandes células B y folicular: 10 años de experiencia del Hospital de Clínicas de Montevideo, Uruguay / Comparison between CHOP-like and R-CHOP in diffuse large B cell and follicular lymphoma
Oliver, Carolina; Guillermo, Cecilia; Martínez, Paula; Díaz, Lilián.
  • Oliver, Carolina; Hospital de Clínicas. Montevideo. UY
  • Guillermo, Cecilia; Hospital de Clínicas. Montevideo. UY
  • Martínez, Paula; Hospital de Clínicas. Montevideo. UY
  • Díaz, Lilián; Hospital de Clínicas. Montevideo. UY
Rev. méd. Chile ; 141(7): 844-852, jul. 2013. ilus
Article in Spanish | LILACS | ID: lil-695765
ABSTRACT

Background:

The most common types of non-Hodgkin lymphoma (NHL) are diffuse large B cell (DLBCL) and follicular (FL).

Aim:

To analyze the benefit ofRituxi-mab in overall survival (OS) of patients with NHL. Material and

Methods:

Review of medical record of 230 adult patients with afirst episode of NHL admitted between 2002 and 2011. We included 67 patients with DLBCL and 36 patients with FL.

Results:

The overall response (OR) was 64% with 39% complete remissions (CR) in DLBCL treated with CHOP-like and 100% with 89% CR with R-CHOP. The median OS with CHOP-like was 21 months versus not attained R-CHOP (p = 0.016). There was a statistically significant difference in median event-free survival (EvFS) in favor of R-CHOP not attained versus 8.3 months for CHOP-like (log rank (p = 0.002)). In FL, the OR in patients treated with R-CHOP or R-CHOP-like was 85%) with 54% CR. With CHOP-like the OR was 59%> with 18% CR. The OS at 24 and 36 months in patients treated with R-CHOP or R-CHOP-like was 83 and 65%. The figures for patients treated with CHOP-like were 80 and 66%> respectively. The progression free survival (PFS) was 21 months with CHOP-like versus not attained with R-QT (p = 0,043).

Conclusions:

When Rituximab was added to CHOP, there was a higher CR, EvFS and OS in DLBCL and higher CR and PFS in FL.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Antineoplastic Combined Chemotherapy Protocols / Lymphoma, Follicular / Lymphoma, Large B-Cell, Diffuse Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Uruguay Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Uruguay Institution/Affiliation country: Hospital de Clínicas/UY

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Full text: Available Index: LILACS (Americas) Main subject: Antineoplastic Combined Chemotherapy Protocols / Lymphoma, Follicular / Lymphoma, Large B-Cell, Diffuse Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Uruguay Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Uruguay Institution/Affiliation country: Hospital de Clínicas/UY