Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación / Uric acid and purine plasma levels as plausible markers for placental dysfunction in pre-eclampsia
Rev. méd. Chile
;
141(7): 895-902, jul. 2013. ilus
Article
in Spanish
| LILACS
| ID: lil-695771
ABSTRACT
Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Placenta
/
Pre-Eclampsia
/
Purines
/
Uric Acid
Type of study:
Risk factors
Limits:
Female
/
Humans
/
Pregnancy
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad del Bío Bío/CL
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