Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010 / Serum levels of alanine aminotransferase in Chilean population: analysis of results of the national health survey 2009-2010
Rev. méd. Chile
;
141(7): 909-916, jul. 2013. ilus
Article
in Spanish
| LILACS
| ID: lil-695772
ABSTRACT
Background:
Determination of Alanine aminotransferase serum levels ([ALT]s) is a sensitive ana reliable test for liver diseases.Aim:
To report the prevalence of abnormal [ALT]s in Chilean population and to identify associated variables.Methods:
We analyzed data from a random sub-sample of 2,794 adults surveyed during the second Chilean National Health Survey. Abnormal [ALT]s were defined by using three different cut-off values (COV), two fixed COV (COV1 > 30 IU/L in men and > 19 IU/L in women and COV2 pre-defined by the performing laboratory) and a COV adjusted by age, weight and sex (COV3 > 31 IU/L for women and > 44 IU/L and men > 42 IU/L and > 66 IU/L with a BMI > 23). Logistic regression analysis was performed to determine risk factors for elevated [ALT]sResults:
Mean [ALT]s values were 30.14 I U/L in men and 22.03 IU/L in women. The observed prevalence of abnormal [ALT]s defined by different COV were 38%, 11.5%, and 8.1% for COV1, COV2 and COV3 respectively. Variables independently associated to abnormal [ALT]s in a multivariate analysis were the following serum gamma-glutamyl-transpeptidase (OR 1.055 [95% CI 1.033-1.078]) and body mass index (OR1.13 [95% CI 1.09-1.17]). Variables inversely associated with abnormal [ALT]s (COV1) were mole gender (OR-.0.976 [95% CI 0.96-0.99) and HDL-cholesterol (OR0979 [95% CI 0.96-0.99]).Conclusions:
Independently of the COV used, Chilean population exhibits a high prevalence of abnormal [ALT]s which may reflect a significant burden of liver disease. Non-alcoholic fatty liver disease could be a major contributor to elevated [ALT]s considering the association of abnormal [ALT]s and metabolic variables.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Alanine Transaminase
Type of study:
Diagnostic study
/
Etiology study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
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