Biomarcadores pronósticos de gravedad del dengue / Biomarkers for the prognosis of severe dengue
Biomédica (Bogotá)
;
33(supl.1): 108-116, set. 2013. graf, tab
Article
in Spanish
| LILACS
| ID: lil-695802
RESUMEN
.
ABSTRACT
Introduction:
There are very few strategies for the early detection of the patients who might develop the severe form of the illness.Objective:
To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. Materials andmethods:
Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness.Results:
ST2, TRAIL and TNF a levels were higher in severe dengue patients compared with uncomplicated patients (p<0.0001), as follows OR=24.8, CI95%= 6.1- 98.0; OR=18.0, CI95%= 4.6-69.1; OR=NC, CI95%= NC, respectively. We did not find statistically significant differences between IDO levels in severe dengue and uncomplicated dengue (p=1.000, OR=1.0, CI95%= 0.2-6.1).Conclusions:
In the early phase of the dengue infection (96 hours), ST2, TRAIL and TNF a quantifications could contribute to the prediction of complications of the illness.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tumor Necrosis Factor-alpha
/
Receptors, Cell Surface
/
Severe Dengue
/
TNF-Related Apoptosis-Inducing Ligand
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Biomédica (Bogotá)
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Universidad Industrial de Santander/CO
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