Your browser doesn't support javascript.
loading
Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal®) coated polypropylene mesh in rabbits
Quinino, Reynaldo Martins e; Araújo-Filho, Irami; Lima, Francisco Piganataro; Barbosa, André Luís Costa; Maia, Tatiana de Carvalho; Goldenberg, Alberto.
  • Quinino, Reynaldo Martins e; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
  • Araújo-Filho, Irami; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
  • Lima, Francisco Piganataro; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
  • Barbosa, André Luís Costa; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
  • Maia, Tatiana de Carvalho; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
  • Goldenberg, Alberto; Rio Grande do Norte Federal University. Integrated Medicine Department. BR
Acta cir. bras ; 28(12): 807-814, Dec. 2013. ilus, tab
Article in English | LILACS | ID: lil-695963
ABSTRACT

PURPOSE:

To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal®) in contact with small bowel in an experimental model in rabbits.

METHODS:

Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal® spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.

RESULTS:

There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.

CONCLUSION:

Polypropylene mesh coated with Coseal® showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polyethylene Glycols / Polypropylenes / Surgical Mesh / Hernia, Abdominal Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Rio Grande do Norte Federal University/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polyethylene Glycols / Polypropylenes / Surgical Mesh / Hernia, Abdominal Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Rio Grande do Norte Federal University/BR