Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
35(4): 432-434, Oct-Dec. 2013. tab
Article
in English
| LILACS
| ID: lil-697323
ABSTRACT
Objective:
To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment.Method:
Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria.Results:
Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine.Conclusion:
Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schizophrenia, Disorganized
/
Schizophrenia, Paranoid
/
Antipsychotic Agents
/
Drug Resistance
/
Clozapine
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Sao Paulo (UNIFESP)/BR
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