Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Acta cir. bras
;
29(1): 7-15, 01/2014. tab, graf
Article
in English
| LILACS
| ID: lil-697552
ABSTRACT
PURPOSE:
To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS:
Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS:
Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS:
Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pesticides
/
Organophosphates
/
Skin
/
Wounds and Injuries
/
Solar Radiation
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Sao Francisco Valley/BR
/
Oswaldo Cruz Institute Foundation/BR
/
São Paulo Federal University/BR
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