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Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs
Frazilio, Fabricio de Oliveira; DeRossi, Rafael; Jardim, Paulo Henrique de Affonseca; Marques, Beatriz Candolo; Martins, Alessandro Rodrigues de Carvalho; Hermeto, Larissa Correa.
  • Frazilio, Fabricio de Oliveira; Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária, Cirurgia e Anestesiologia. Campo Grande. BR
  • DeRossi, Rafael; Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária, Cirurgia e Anestesiologia. Campo Grande. BR
  • Jardim, Paulo Henrique de Affonseca; s.af
  • Marques, Beatriz Candolo; s.af
  • Martins, Alessandro Rodrigues de Carvalho; s.af
  • Hermeto, Larissa Correa; s.af
Acta cir. bras ; 29(1): 38-46, 01/2014. tab, graf
Article in English | LILACS | ID: lil-697559
ABSTRACT
To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.

METHODS:

Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic.

RESULTS:

A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose.

CONCLUSION:

Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Analgesics / Isoflurane / Anesthesiology Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Analgesics / Isoflurane / Anesthesiology Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR