Local and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping
Clinics
;
68(12): 1548-1554, dez. 2013. tab, graf
Article
in English
| LILACS
| ID: lil-697712
ABSTRACT
OBJECTIVES:
This study tests the hypothesis that local or remote ischemic preconditioning may protect the intestinal mucosa against ischemia and reperfusion injuries resulting from temporary supraceliac aortic clamping.METHODS:
Twenty-eight Wistar rats were divided into four groups the sham surgery group, the supraceliac aortic occlusion group, the local ischemic preconditioning prior to supraceliac aortic occlusion group, and the remote ischemic preconditioning prior to supraceliac aortic occlusion group. Tissue samples from the small bowel were used for quantitative morphometric analysis of mucosal injury, and blood samples were collected for laboratory analyses.RESULTS:
Supraceliac aortic occlusion decreased intestinal mucosal length by reducing villous height and elevated serum lactic dehydrogenase and lactate levels. Both local and remote ischemic preconditioning mitigated these histopathological and laboratory changes.CONCLUSIONS:
Both local and remote ischemic preconditioning protect intestinal mucosa against ischemia and reperfusion injury following supraceliac aortic clamping. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aorta, Abdominal
/
Reperfusion Injury
/
Ischemic Preconditioning
/
Intestinal Mucosa
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Ciencias da Saude de Porto Alegre/BR
Similar
MEDLINE
...
LILACS
LIS