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In situ protocol for the determination of dose-response effect of low-fluoride dentifrices on enamel remineralization
AFONSO, Rebeca Lima; PESSAN, Juliano Pelim; IGREJA, Bruna Babler; CANTAGALLO, Camila Fernandes; DANELON, Marcelle; DELBEM, Alberto Carlos Botazzo.
  • AFONSO, Rebeca Lima; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
  • PESSAN, Juliano Pelim; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
  • IGREJA, Bruna Babler; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
  • CANTAGALLO, Camila Fernandes; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
  • DANELON, Marcelle; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
  • DELBEM, Alberto Carlos Botazzo; Univ. Estadual Paulista. Aracatuba Dental School. Department of Pediatric Dentistry and Public Health. Aracatuba. BR
J. appl. oral sci ; 21(6): 525-532, Nov-Dec/2013. graf
Article in English | LILACS, BBO | ID: lil-697811
ABSTRACT
No in situ protocol has assessed the dose-response effects of fluoride dentifrices involving low-fluoride formulations.

Objective:

To assess the ability of an in situ remineralization model in determining dose-response effects of dentifrices containing low fluoride concentrations ([F]) on bovine enamel. Material and

Methods:

Volunteers wore palatal appliances containing demineralized enamel blocks and brushed their teeth and devices with the dentifrices supplied (double-blind, crossover protocol) separately for 3 and 7 days. Surface hardness (SH), integrated subsurface hardness (ΔKHN) and [F] in enamel were determined. Data were analyzed by ANOVA, Tukey's test and Pearson's correlation (p<0.05).

Results:

Dose-response relationships were verified between [F] in dentifrices and SH, ΔKHN and enamel [F]. Higher correlation coefficients between enamel [F] and SH and ΔKHN were obtained for the 3-day period. Significant differences in SH and ΔKHN were observed among all groups for the 3-day period, but not between 0-275, 275-550, and 550-1,100 µg F/g dentifrices for the 7-day period, nor between 3- and 7-day periods for the 1,100 µg F/g groups.

Conclusions:

Considering that the peak remineralization capacity of the conventional dentifrice (1,100 µg F/g) was achieved in 3 days, this experimental period could be used in future studies assessing new dentifrice formulations, especially at low-fluoride concentrations. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tooth Remineralization / Tooth Demineralization / Dental Enamel / Dentifrices / Fluorides Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Univ. Estadual Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tooth Remineralization / Tooth Demineralization / Dental Enamel / Dentifrices / Fluorides Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Univ. Estadual Paulista/BR