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Circadian clock of Aedes aegypti: effects of blood-feeding, insemination and RNA interference
Gentile, Carla; Rivas, Gustavo Bueno da S; Lima, Jose BP; Bruno, Rafaela Vieira; Peixoto, Alexandre Afranio.
  • Gentile, Carla; Laboratorio de Biologia Molecular.
  • Rivas, Gustavo Bueno da S; Laboratorio de Biologia Molecular.
  • Lima, Jose BP; Laboratorio de Biologia Molecular.
  • Bruno, Rafaela Vieira; Laboratorio de Biologia Molecular.
  • Peixoto, Alexandre Afranio; Laboratorio de Biologia Molecular.
Mem. Inst. Oswaldo Cruz ; 108(supl.1): 80-87, 2013. tab, graf
Article in English | LILACS | ID: lil-697824
ABSTRACT
Mosquitoes are the culprits of some of the most important vector borne diseases. A species’ potential as a vector is directly dependent on their pattern of behaviour, which is known to change according to the female’s physiological status such as whether the female is virgin/mated and unfed/blood-fed. However, the molecular mechanism triggered by and/or responsible for such modulations in behaviour is poorly understood. Clock genes are known to be responsible for the control of circadian behaviour in several species. Here we investigate the impact mating and blood-feeding have upon the expression of these genes in the mosquito Aedes aegypti . We show that blood intake, but not insemination, is responsible for the down-regulation of clock genes. Using RNA interference, we observe a slight reduction in the evening activity peak in the fourth day after dstim injection. These data suggest that, as in Drosophila , clock gene expression, circadian behaviour and environmental light regimens are interconnected in Ae. aegypti .
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Full text: Available Index: LILACS (Americas) Main subject: Photoperiod / Aedes / RNA Interference / CLOCK Proteins / Circadian Clocks / Insemination Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2013 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Photoperiod / Aedes / RNA Interference / CLOCK Proteins / Circadian Clocks / Insemination Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2013 Type: Article