Efecto de la hidroxicloroquina sobre la sensibilidad a la insulina y el perfil de lípidos en pacientes con artritis reumatoide / Effects of hydroxychloroquine on insulin sensitivity and lipid profile in patients with rheumatoid arthritis
Rev. méd. Chile
;
141(8): 1019-1025, ago. 2013. tab
Article
in Spanish
| LILACS
| ID: lil-698700
ABSTRACT
Background:
Rheumatoid arthritis (RA) is associated with a decrease in insulin sensitivity (IS), which has been identified as an independent risk factor for the development of early atherosclerosis. Hydroxychloroquine (HCQ) may have beneficial effects on glucose homeostasis and lipid profile.Aim:
To assess the effect of HCQ on IS and lipid profile in patients with RA. Material andMethods:
An open clinical trial was performed in 15 patients aged between 35 and 56 years. During three months, patients received 400 mg/day of HCQ orally. Before and after the pharmacological intervention, demographic and anthropometric variables, serum glucose, total cholesterol (TC), triglycerides (TG), HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, insulin and uric acid were measured. IS was estimated as the rate of glucose clearance per minute obtained with the insulin tolerance test (KITT).Results:
Baseline and final KITT values were 4.3 ± 1.2 and 4.80 ± 1.1%/min, respectively (p = 0.03). Significant reductions in serum TC (p = 0.04) and TG (p = 0.01) were also observed. No other significant differences were observed.Conclusions:
Oral administration of 400 mg/day of HCQ during three months in RA patients is associated with an improvement in IS, TC and TG.
Full text:
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Index:
LILACS (Americas)
Main subject:
Arthritis, Rheumatoid
/
Insulin Resistance
/
Antirheumatic Agents
/
Lipid Metabolism
/
Hydroxychloroquine
Type of study:
Diagnostic study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX
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