Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Rev. bras. hematol. hemoter
;
35(6): 414-416, 2013. tab, graf
Article
in English
| LILACS
| ID: lil-699991
ABSTRACT
Background:
The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking.Objective:
The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization.Methods:
This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels.Results:
The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index.Conclusion:
It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Transfusion
/
Blood Transfusion, Autologous
/
C-Reactive Protein
/
Erythrocyte Transfusion
/
Allergy and Immunology
/
Immune System Phenomena
/
Isoantibodies
/
Neoplasms
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hemocentro de Sao Paulo/BR
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