Immune responses to Leptospira infection: roles as biomarkers for disease severity
Braz. j. infect. dis
;
18(1): 77-81, Jan-Feb/2014. graf
Article
in English
| LILACS
| ID: lil-703044
ABSTRACT
Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cytokines
/
Immunity, Innate
/
Leptospirosis
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2014
Type:
Article
/
Project document
Affiliation country:
Thailand
Institution/Affiliation country:
Chulalongkorn University/TH
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