Your browser doesn't support javascript.
loading
Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Fecury, Amanda Alves; Almeida, Marcella Kelly Costa de; Santos, Kemper Nunes dos; Freitas, Andrei da Silva; Dantas, Socorro de Fatima Loureiro; Costa, Carlos Araujo da; Crescente, Angelo Barlleta; Sousa, Rita Catarina Medeiros de; Brito, Elza Baia de; Nassiri, Reza; Lampe, Elizabeth; Martins, Luisa Caricio.
  • Fecury, Amanda Alves; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Almeida, Marcella Kelly Costa de; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Santos, Kemper Nunes dos; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Freitas, Andrei da Silva; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Dantas, Socorro de Fatima Loureiro; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Costa, Carlos Araujo da; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Crescente, Angelo Barlleta; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Sousa, Rita Catarina Medeiros de; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Brito, Elza Baia de; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Nassiri, Reza; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Lampe, Elizabeth; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
  • Martins, Luisa Caricio; Universidade Federal do Para. Nucleo de Medicina Tropical. Laboratorio de Patologia Clinica das Doencas Tropicais. Belem. BR
Rev. Soc. Bras. Med. Trop ; 47(1): 90-92, Jan-Feb/2014. tab
Article in English | LILACS | ID: lil-703154
ABSTRACT

Introduction:

The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression.

Methods:

Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation.

Results:

Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis.

Conclusions:

HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. .
Subject(s)

Fulltext
Print
XML
Search on Google

Full text: Available Index: LILACS (Americas) Main subject: Hepacivirus / Hepatitis C, Chronic / Liver Cirrhosis Type of study: Diagnostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Para/BR

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google

Full text: Available Index: LILACS (Americas) Main subject: Hepacivirus / Hepatitis C, Chronic / Liver Cirrhosis Type of study: Diagnostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Para/BR