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In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon
Ribatski-Silva, Daniele; Bassi, Carmen Lucia; Martin, Thamires Oliveira Gasquez; Alves-Junior, Eduardo; Gomes, Luciano Teixeira; Fontes, Cor Jesus Fernandes.
  • Ribatski-Silva, Daniele; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
  • Bassi, Carmen Lucia; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
  • Martin, Thamires Oliveira Gasquez; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
  • Alves-Junior, Eduardo; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
  • Gomes, Luciano Teixeira; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
  • Fontes, Cor Jesus Fernandes; Universidade Federal de Mato Grosso. Faculdade de Medicina. Pos-Graduacao em Ciencias da Saude. Cuiaba. BR
Rev. Soc. Bras. Med. Trop ; 47(1): 110-112, Jan-Feb/2014. tab
Article in English | LILACS | ID: lil-703166
ABSTRACT

Introduction:

We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.

Methods:

A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.

Results:

The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI) 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.

Conclusions:

Tigecycline may represent an alternative drug for the treatment of patients with severe malaria. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Proteins / Minocycline / Antimalarials Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Mato Grosso/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Proteins / Minocycline / Antimalarials Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Mato Grosso/BR