In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon
Rev. Soc. Bras. Med. Trop
;
47(1): 110-112, Jan-Feb/2014. tab
Article
in English
| LILACS
| ID: lil-703166
ABSTRACT
Introduction:
We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.Methods:
A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.Results:
The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI) 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.Conclusions:
Tigecycline may represent an alternative drug for the treatment of patients with severe malaria. .
Full text:
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Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Proteins
/
Minocycline
/
Antimalarials
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Mato Grosso/BR
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